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Peptic Ulcer

Treatment For Peptic Ulcer

A peptic ulcer is the result of hyperacidity, which is caused by an increase in the hydrochloric acid in the stomach. This strong acid, secreted by the cells lining the stomach, erodes the inner lining of the stomach. Dietetic indiscretion such as overeating, taking of heavy meals or highly spiced foods, coffee, alcohol, and smoking are the main factors contributing to this condition.
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Causes

Causes of acid peptic disease include:

  • Helicobacter pylori: H.pylori is responsible for around 60%-90% of all gastric and duodenal ulcers.
  • NSAIDs: Prostaglandins protect the mucus lining of the stomach. Non steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, diclofenac and naproxen prevent the production of these prostaglandins by blocking cyclo-oxygenase enzyme leading to ulceration and bleeding.
  • Smoking, alcohol and tobacco: Cigarettes, alcohol and tobacco cause an instant and intense acid production.
  • Blood group O: People with blood group “O” are reported to have higher risks for the development of stomach ulcers as there is an increased formation of antibodies against the Helicobacter bacteria, which causes an inflammatory reaction and ulceration.
  • Heredity: Patients suffering from peptic ulcer diseases usually have a family history of the disease, particularly the development of duodenal ulcer which may occur below the age of 20.
  • Steroids/Other medicines: Drugs like corticosteroids, anticoagulants like warfarin (Coumadin), niacin, some chemotherapy drugs, and spironolactone can aggravate or cause ulcers.
  • Diet: Low fiber diet, caffeinated drinks and fatty foods are linked to peptic ulcer.
  • Other diseases: Chronic liver, lung and kidney diseases especially tumors of the acid producing cells all predispose to peptic ulcers. Zollinger-Ellison Syndrome (ZES) is a rare pre-cancerous condition which causes peptic ulcer disease. It is a syndrome disorder wherein tumors in the pancreas and duodenum also known as gastrinomas produce a large amount of gastrin which is a hormone that stimulates gastric acid secretion. Endocrine disorders such as hyperparathyroidism are also implicated in the development of peptic ulcers.
  • Stress: Stress and neurological problems can also be associated with the Cushing ulcer and peptic ulcer.

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